Empty capsules, semubatsiri akakosha mumaindasitiri ezvemishonga uye ehutano ekuwedzera, ane maitiro ekugadzira anobatanidza chaiyo makemikari engineering uye otomatiki tekinoroji. Izvi zvinofanirwa kuitwa munzvimbo dzakachena kuti ive nechokwadi chekuchengetedza, kufanana, uye kugadzikana kwezvigadzirwa. Iyo yese maitiro inogona kupatsanurwa kuita mashanu epakati matanho: mbishi kugadzirisa, kuumba, kuomesa, kupedzisa, uye kurongedza.
Raw zvinhu kugadzirira uye solubilization ndiyo hwaro. Iyo mikuru yezvigadzirwa zvema capsules asina chinhu ndeyemishonga gelatin (inotorwa kubva paganda remhuka nemapfupa) kana chirimwa cellulose (senge hydroxypropyl methylcellulose), iyo inofanirwa kupfuura yakanyatso ongororo yemhando isati yashandiswa. Munguva yekugadzira, gelatin kana chirimwa chingamu uye mvura yakachena inowedzerwa zvakaenzanirana kune solubilization tangi, pamwe chete neakakodzera huwandu hweplasticizers (senge glycerin) uye colorants seyekubatsira zvinhu. Mumamiriro ekunze etembiricha, anokwizwa nekuzvimba kuita yunifomu, -free gel solution. Iyo viscosity, fungidziro, pH kukosha uye mamwe ma parameter eiyo gel mhinduro inoda kunyatsodzorwa, sezvo inokanganisa zvakananga kunaka kwekutevera kuumbwa.
Dip Molding ndiyo musimboti muitiro. Iyo sol inotakurwa kuburikidza ne insulated mapaipi kumuchina wekudhibha. Iyo molds (kazhinji yakagadzirwa nesimbi isina tsvina yetsono molds) inofanopisa uye inocheneswa isati yanyudzwa musol. Nokudzora kudzika kwekunyura, kugara nguva uye kukurumidza kusimudza, yunifomu ye sol inonamatira pamusoro pezviumbwa. Zviumbwa kana zvanyudzwa zvinopinda mupre-bhokisi rekuomesera uye zvinotanga kuumbwa munzvimbo yakadzikira-inodziya uye yakaderera-yakanyorova, zvichiita kuti sol inyunguduke uye igadzire membrane yakapfava. Iyi nhanho ine zvakanyanyisa zvinodikanwa zvekunyatso kuumbwa uye tembiricha gradient control, ichinyatso tarisa ukobvu hwemadziro, kutenderera uye elasticity yemacapsules.
Kuomesa uye kugadzira kwakakosha pakugadzikana kwechigadzirwa. Iyo yakatanga kuumbwa capsule membranes inopinda mugero guru rekuomesera pamwe chete ne molds. Pasi pemamiriro ekuwedzera tembiricha (senge kubva pa25℃kusvika 40 degree) uye humidity inodzorwa, inoramba ichiomeswa kweanoverengeka kusvika kweanopfuura maawa gumi kusvikira mwando wegelatin film wadonha kusvika pakachengeteka (kazhinji 10% kusvika 15%). Mushure mekuomeswa kwapera, macapsules anobviswa zvinyoronyoro kubva mumichini kana nemaoko, zvichiita kuti pave nehafu{7}}yakapedzwa zvigadzirwa zvema capsules asina chinhu, capsule caps nemiviri.
Kucheka, kuronga uye kuongorora kunovimbisa kunaka kwezvigadzirwa zvakapedzwa. Mushure mekudhirowa, iyo capsule caps nemitumbi inoda kupfuura nenzira yekucheka kuti icheke migumo yese kusvika paurefu hwakatarwa, nenzvimbo dzakachekwa dzichitsetseka uye dzisina maburrs. Zvadaro, midziyo yekuongorora inoshandiswa kubvisa zvinhu zvakakanganisika zvakadai sezvakaremara, zvakakuvadzwa kana zvakanamatira, uye zvinorongwa nehukuru, ruvara, nezvimwewo. Zvigadzirwa zvakapedzwa zvinoda kuongororwa maitiro akawanda emhando, kusanganisira friability, disintegration nguva, microbial limits, heavy metal content, nezvimwewo, kuti ave nechokwadi chekuteerera mitemo ye pharmacopoeia.
Packaging ndiro danho rekupedzisira. Macapsules asina chinhu anopfuura pakuongorora anonamwa mumabhegi akapetwa kaviri-akachena uye ozoiswa mumabhegi ealuminium foil kana mabhaketi epurasitiki, ane nhamba dzebatch dzekugadzirwa, mazuva ekupera kwebasa uye mamwe mashoko akaiswa paari. Vanochengetwa munzvimbo inotonhorera uye yakaoma kudzivirira unyoro uye deformation.
Nzira yekugadzira yecapsules isina chinhuyakanyatsobatanidzwa, ine akawanda emhando yekudzora mapoinzi kubva kune yakabikwa kusvika kune yakapera zvigadzirwa. Kushanda zvine hungwaru uye kutarisisa kwakasimba padanho rega rega rakabatana gadzira iyo Safety Core yeiyi kapisi diki, ichipa vimbiso yakavimbika yekuuyisa kunoshanda kwegadziriro yezvinodhaka. Kana paine chero chinodiwa pamacapsules asina chinhu, unogamuchirwa kubata KornnacCaps.
