Seyakajairika fomu yedosi yemishonga, kutorwa kwekapisi kunosanganisira akawanda matanho. Kubva kupinda mumuviri wemunhu kusvika pakushandisa kurapa kwayo, nhanho yega yega inokonzereswa nehunhu uye mushonga-zvakanangana. Iyi inotevera tsananguro yakadzama inovhara kuparara kwecapsule, kuburitswa kwezvinodhaka, nzira dzekunyudza, uye zvinofurira zvinhu.
Kutora kunotanga nekuparara kwe capsule mugumbo rekudya. Mushure mekudyiwa, capsule inofamba ichidzika negurokuro ichienda mudumbu, umo gastric acid uye ma enzymes ekugaya anotanga kushanda pagoko rayo. Makapule shells anowanzo gadzirwa kubva kuzvinhu zvakaita segelatin kana chirimwa-based cellulose. Zvinhu izvi zvishoma nezvishoma zvinopfava uye pakupedzisira zvinoputika kana kunyungudika munzvimbo ine acidic yemudumbu uye alkaline nharaunda yematumbu. Nguva yechiitiko ichi inosiyana zvichienderana nekuumbwa kwecapsule uye mutsauko wega wega, asi inowanzogara mudumbu kwemaminetsi makumi matatu kusvika maawa maviri. Chete mushure mekunge goko ranyungudika zvachose mushonga unogona kuburitswa.
Kuburitswa kwezvinodhaka inhanho yakakosha yekunwa. Kana iyo capsule shell yanyunguduka, mukati memishonga zvimedu kana hupfu zvinoburitswa mudumbu kana mudumbu zvinwiwa. Mutengo wekusunungurwa unogona kusiyana kune zvinodhaka zvakasiyana-siyana; mamwe akagadzirirwa kuburitswa nekukasika, asi mamwe anoburitswa zvishoma nezvishoma, zvichienderana nemagadzirirwo akaitwa, akadai semazuva ese, akagariswa-akaburitswa, kana akadzorwa-akaburitsa makapisi. Mushonga wakasunungurwa unogona kunge uri muchimiro chegranules, poda, kana mvura, uye chimiro chayo chemuviri chinokanganisa kupera kwayo uye kupararira kwekukurumidza mumugwagwa wekudya.
Nzvimbo yekutanga yekutorwa kwezvinodhaka idumbu diki. Ura hudiki ndiyo nzvimbo huru yekutora zvinodhaka, sezvo mucosal wayo wakafukidzwa mu microvilli, iyo inowedzera zvakanyanya nzvimbo. Uyezve, kutakura mapuroteni pamasero epithelial emukati mudiki anogona kusarudza kutakura mamorekuru emishonga. Mamorekuru emushonga anoyambuka gastrointestinal mucosa kuburikidza nepassive diffusion kana kufambisa kutakura kupinda mucirculatory system. Iko kumhanya uye kugona kwekunyura kunokonzerwa nezvakawanda zvinhu, zvinosanganisira mushonga we physicochemical zvimiro senge mamorekuru, solubility, uye lipophilicity, pamwe nepermeability uye ukobvu hwecapsule zvinhu.
Nguva yekutora zvinodhaka yakafaranuka, kazhinji kubva pamaminitsi makumi matatu kusvika kumaawa matanhatu. Mishonga yezvinwiwa inomwiwa nekukurumidza kupfuura yakasimba, ukuwo capsule{{3}based drugs inotorwa mukati memaawa maviri kusvika matatu, nekugara-magadzirirwo ekuburitswa achitora nguva yakareba. Pamusoro pezvo, misiyano yemunhu inogona kukanganisa kunyudzwa, kusanganisira zera, bonde, majini, uye gut microbiome. Iyo gut microbiome inogona kupesvedzera zvisina kunanga kunyudzwa kwezvinodhaka nekugadzirisa mushonga kana kugadzirisa nharaunda yehutu.
Pakupedzisira, mushure mokupinda muropa, mishonga yakawanda inopinda mumetabolism muchiropa, iyo inoshandurwa kuva zvinhu zvisingashandisi isati yabudiswa neitsvo. Mimwe mishonga inogona kubudiswa zvakananga neitsvo pasina kushandiswa kwemetabolism. Iyi nzira inovimbisa kugovera kunoshanda uye kubviswa kwemushonga kubva mumuviri.
Muchidimbu, kutorwa kwecapsule inzira yakaoma uye chaiyo inosanganisira kupatsanurwa kwegoko, kuburitswa uye kutorwa kwemushonga, uye pesvedzero yekusiyana kwega. Kunzwisisa kwakakodzera kwemaitiro aya kwakakosha pakushandisa zvine musoro kwemushonga, kuve nechokwadi chekuchengetedza kwayo uye kushanda kwayo. Kana pane zvinodiwacapsules isina chinhu, unogamuchirwa kuti ubate KornnacCaps.
