Muindasitiri yemishonga uye inovaka muviri, capsules isina chinhu inoshanda sevatakuri vezvinodhaka. Basa ravo repakati harisi rekuvhara zviri mukati chete asi, kunyanya kukosha, kuputika nekukasira panzvimbo dzakati mukati memuviri kuti ubudise mushonga. Nguva yekuparadzana inoreva nguva inodiwa kuti capsule ichinje kubva kune yakasimba kuenda kune isina kubvongodzwa mune yakatsanangurwa svikiro; ichi ndicho chiratidzo chikuru chekuyera capsule quality. Nekuda kwekusiyana kwechimiro chemakemikari uye zvimiro zvemuviri, mhando dzakasiyana dzeasina chinhu capsules dzinoratidza misiyano yakakosha mumiganhu yavo yenguva yekuparara.
Parizvino, macapsules emazuva ese asina chinhu pamusika akakamurwa kuita gelatin capsules (mhuka-yakatorwa) uye yemiriwo capsules (kunyanya HPMC capsules uye Pullulan capsules).
Chekutanga,gelatin capsulesndiwo manyorerwo emhando yepamusoro ane nhoroondo refu. Chikamu chavo chikuru chinotorwa kubva kuganda remhuka uye bone collagen, ine yakanakisa hydrophilicity. Munzvimbo yakajairwa gastric fluid (37 degree, aqueous medium), gelatin capsules inotora mvura uye inowedzera nekukurumidza, negoko rinokurumidza kupfava uye kunyungudika. Zvinoenderana neChinese Pharmacopoeia uye akakodzera zviyero, iyo nguva yekuparadzana muganho wegelatin capsules inowanzodikanwa kuve mukati memaminitsi makumi matatu. Nekuda kwekunyungudika kwemvura-yawo, mapiritsi egelatin anopa kukurumidza kutanga uye ndiyo sarudzo inodiwa pamishonga yakawanda yakajairika.
Chechipiri,HPMC capsulesndiwo anonyanya kushandiswa miriwo capsules. Kusiyana negelatin, HPMC ndeye cellulose derivative ine yakagadzikana chimiro chemakemikari. Iyo nzira yeHPMC capsule dissolution mumvura ine yakaderera correlation nekushisa uye haina kunyanya kukanganiswa nepH kukosha. Kunyangwe hazvo nguva yavo yekuparadzana ichienderanawo nezvinodiwa zvepharmacopoeia mukati memaminitsi makumi matatu, HPMC capsules inowanzo ratidza yakagadzikana hunhu hwekuparara panguva chaiyo yekuparara. Kunyanya munzvimbo dzakaderera-kana kuti-nemwando wepamusoro, HPMC capsules inochengetedza brittleness uye kunyungudika kwakanaka; havatamburi nekuparadzana kwakawedzerwa nekuda kwe-kusangana kwekuita (kuchembera) sezvinoita gelatin capsules dzimwe nguva.
Pamusoro pezvo, kune zvinodiwa zvakanyanya, kune enteric-yakavharidzirwa capsules uye akabatikana{1}}akaburitsa capsules. Zvisinei nekuti matrix igelatin here kana kuti faibha yechirimwa, enteric-makapisi akavharidzirwa anorapwa kana kugadzirisa kemikari. Izvo hazviparare mugastric acid nharaunda uye inongonyungudika mushure mekupinda chaiyo pH nharaunda yeura. Nguva yavo yekuparadzana inowanzodikanwa kuti ive mukati meawa imwe mune yekugadzira intestinal fluid, iyo inowira pasi pechikamu chekudzora kusunungurwa.
Mukupfupisa, yakajairwa gelatin capsules uye yemiriwo capsules ine yakafanana yakajairwa disintegration nguva miganhu (zvese mukati me30 maminetsi), asi yemiriwo capsules inoita zvirinani maererano nekugadzikana pasi penzvimbo dzakanyanyisa uye kuramba kuchembera. Pakusarudza mhando dzemacapsule, makambani emishonga anofanirwa kutarisisa zvizere madhiragi, mamiriro ekuchengetera, uye chaizvo zvinodikanwa zvekuparara kwekumhanya kuti ive nechokwadi chekuwana bioavailability yemushonga.
