HPMC Empty Capsules chigadzirwa chine pfungwa yechisikigo, uye zvinhu zvayo uye maitiro ekugadzira zvinozivikanwa nevechiJudha, Islamic uye vegetarian associations, izvo zvinogona kuzadzisa zvinodiwa nevanhu vezvitendero zvakasiyana-siyana uye maitiro ekudya, uye ane kugamuchirwa kwakanyanya. Pamusoro pe,HPMCempty capsulesvane zvinotevera zvakasiyana zvivakwa:
Mvura Yakaderera - Zvingangoita 60% Yakaderera Pane Iyo YeGelatin Empty Capsules
Mvura yegelatin capsules inowanzoita 12.5%-17.5%. Zvingave zviri mukati mekugadzirwa kwe capsule isina chinhu, kutakura, kushandiswa nekuchengetedza, tembiricha uye hunyoro hwemamiriro ekunze hunofanirwa kudzorwa munzvimbo yakakodzera. Iyo tembiricha yakakodzera ndeye 15-25 dhigirii uye hunyoro hunyoro ndeye 35% -65%, kuitira kuti kushanda kwechigadzirwa kuchengetedzwe kwenguva yakareba. Mvura yemukati yeHPMC membrane yakadzika kwazvo, kazhinji 4% -5%, iyo inenge 60% yakaderera pane iyo yegelatin capsules. Kutsinhana kwemvura nemhoteredzo mukuchengetedza kwenguva refu kuchawedzera huwandu hwemvura yeHPMC isina chinhu capsules mupakatarwa, asi haizopfuure 9% mumakore mashanu.
Iyo yakaderera mvura yemukati inoita HPMC isina chinhu capsules akakodzera kuzadza nehygroscopic kana mwando inonakira zvirimo kuti uwedzere hupenyu hwesherufu yechigadzirwa.
High Toughness, Hapana Brittle Breakage
Sezvambotaurwa pamusoro apa, iyo gelatin firimu ine yakatsanangurwa mwando, kana iri pasi pemuganhu uyu, iyo gelatin film ichave yakanyanya brittle. Kana iyo mvura yemukati yeyakajairwa isina chinhu gelatin capsules isina chero ekuwedzera iri 10%, njodzi yebrittleness inodarika 10%. Kana mwando ukaramba uchideredzwa kusvika pa5%, 100% brittle ichaonekwa. Mukupesana, HPMC isina chinhu capsules ine zvirinani kuomarara uye inochengetedza kuita kwakanaka kunyangwe nehunyoro hwakaderera. Ehe, iyo brittleness mwero weHPMC capsules ane akasiyana maregisheni anozosiyana zvakanyanya pasi pehunyoro hwakaderera.
Pane zvinopesana, gelatin capsules inoiswa munzvimbo ine hunyoro hwepamusoro, uye goko richava rakapfava, rakaremara, uye kunyange kudonha mushure mekutora mvura. HPMC isina chinhu capsules inogona kuchengetedza chimiro chakanaka uye kushanda kunyangwe pasi pe-mwando wepamusoro. Nekuda kweizvi, HPMC capsules ine kuchinjika kwakasimba kune zvakatipoteredza, uye mukana weHMPC capsules unonyanya kukosha kana nzvimbo yekutengesa yechigadzirwa ichivhara nzvimbo dzakasiyana dzemamiriro ekunze kana mamiriro ekuchengetedza ari mashoma.
Yakasimba Kemikari Kugadzikana
Iyo crosslinking reaction yegelatin capsules idambudziko rakaoma rinosangana ne capsule kugadzirira. Nemhaka yokuti boka re aldehyde rezviri mukati rinopindirana neboka reamino yeamino acids mugelatin kuti iite network network, iyo capsule shell yakaoma kunyunguduka pasi pemamiriro ekuparara mu vitro, izvo zvinokanganisa kusunungurwa kwemushonga. Hydroxypropyl methylcellulose inobuda mu cellulose ine makemikari inert uye inonyatsoenderana nezvinhu zvakawanda, saka macapsules eHPMC haave nenjodzi yekuyambuka-linking reaction uye ane yakanyanya kugadzikana kwemakemikari.
Yakanaka Coating Performance
MaEnteric{{0}coated capsules anoshandiswa zvinodhaka zviri nyore kukuvadzwa neacid yemudumbu, inovava mugastric mucosa, kana kuti inoda kurongedzerwa. Iyo inogamuchirwa pasi rose enteric capsule tekinoroji ndeye enteric pellet uye capsule integral coating. HPMC capsules inoratidza yakasarudzika mabhenefiti mune yakazara coating yemacapsules.
Tsvagiridzo inoratidza kuti HPMC isina chinhu kapisi ine nzvimbo yakakasharara, uye hukama hwayo nemafuta akawanda-yakavharwa zviri pachena kuti yakakwirira kudarika gelatin. Kukurumidza kwekunamatira uye kufanana kwezvinhu zvekuputira zviri pachena zviri nani kupfuura gelatin, kunyanya kuvimbika kwechifukidzo pamusangano wemuviri uye chivharo chinovandudzwa zvakanyanya. Iyo vitro dissolution bvunzo yakaratidza kuti HPMC capsule yakavharwa yaive yakaderera permeability mudumbu uye kuburitswa kwakanaka muura.
Hunhu hweHPMC capsules hunoita kuti munda wayo wekushandisa uwedzere kuenderera. Kubva kune-zvigadzirwa zvechisikigo kusvika kune zvinonzwa mwando kana kuti hygroscopic mukati, nhasi kune mamwe mashandisirwo akasiyana-siyana mundima yehupfu hwakaomeswa hwekufemesa uye ma enteric coatings. Zvinofanira kucherechedzwa kuti HPMC isina chinhu capsules parizvino yakanyorwa muChina nekune dzimwe nyika ine yakakwira okisijeni permeability uye zvishoma zvishoma kuparara pane gelatin isina capsules, asi bioavailability yavo mu vivo yakafanana, iyo inofanirwa kutariswa mukutsvaga nekusimudzira. Kana paine chero zvinodikanwa pamacapsules asina chinhu, unogamuchirwa kubata KornnacCaps!
