Wakambozvibvunza here kuti sei ivo vakangwara kana iwe ukawana capsules mubhokisi rako remishonga inoda kutorwa pasina chinhu mudumbu hazvikonzerese kusagadzikana mudumbu? Mhinduro iri mugoko rawo rekunze, iro enteric-yakavharwa capsule. Saka, chii chaizvoenteric-yakapfekwacapsulesyakagadzirwa ne? Nhasi, ngatisimudze chidzitiro pachakavanzika chayo.
Core Zvikamu: Shanduko yeGelatin kana Plant Gel
Zvinhu zvakakosha zveenteric-coated capsules zvinonyanya kunzi gelatin. Gelatin ipuroteni yakatorwa kubva mumapfupa emhuka kana paganda, inozivikanwa nefirimu rayo rakanaka-kuumba zvimiro uye kugarisana kwehupenyu, zvichiita kuti ive sarudzo yechinyakare yekugadzira mateko emakapisi akajairwa. Kuti usangane nezvinodiwa zvemimwe mishonga yedumbu redumbu, izvi zvakakosha zvinhu zvinoda yechipiri kugadzirisa.
Chinhu Chinokosha: The Enteric Coated Layer
Chikonzero nei enteric-yakaputirwa capsules ichiramba yakasimba-yakasimba mudumbu uye pakarepo ichiputsika muura inorara muchikamu chakakosha che enteric coated pamusoro peganda re capsule. Iyi yekuputira zvinhu ndiyo kiyi yekuona kuita kwayo. Zvakajairika enteric{{4}zvakavharidzirwa zvinonyanya kuwira muzvikamu zviviri:
Cellulose Derivatives: Zvakadai se cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HPMCP), etc. Zvinhu izvi zvakanyatsogadzikana uye zvinenge zvisingasviki mumamiriro e acidic yegastric juice, nokudaro kudzivirira mushonga wemukati. Kana iyo capsule ichisvika mudumbu nharaunda ine pH yakakwira, zvinhu izvi zvinonyungudika, zvichiita kuti ganda recapsule rivhuke uye risunungure mushonga.
Acrylic Resins: Marezeni aya anewo hunhu hwekugadzikana munzvimbo dzine acidic uye kunyungudika munzvimbo dzine alkaline, achidziita chimwe chinowanzo shandiswa enteric zvinhu.
Zvinodikanwa Zvinodiwa: Kudyara-Kune dzimwe nzira
Tichitarisa zvinodikanwa zvemamwe mapoka evanhu (sevanodya miriwo kana avo vasingawirirani nezvigadzirwa zvemhuka), kune zvakare maenteric{0}makapisi akavharidzirwa pamusika anogadzirwa nejeli rechirimwa (senge HPMC) sebhesi obva agadziriswa ne enteric coating. Izvi zvinopa dzimwe sarudzo kune varwere.
Internal Space: The Drug's Safe Haven
The Empty part ye enteric-coated capsule yakagadzirwa kuti ikwane mushonga. Inogona kuzadzwa nemhando dzakasiyana dzeyero yemishonga, angave ari hupfu, granules, kana pellets. Asidhi iyi-resistant capsule shell inoita senzvimbo yakachengeteka kwechinguvana, ichiona kuti mushonga unoramba wakagadzikana usati wasvika panzvimbo yauri kuda (ura), hauparadzwe neacid yemudumbu, uyezve unodzivirira kushatirwa kugastric mucosa.
Muchidimbu: Muchengeti Wehutano Akagadzirwa Zvamazvirokwazvo
Mukupedzisa,enteric-coated capsuleinoumbwa neyakagadzika zvinhu (gelatin kana chirimwa gel) uye yakakosha enteric coating layer (yakadai seCAP, HPMCP, nezvimwewo). Iyi chaiyo dhizaini inoibvumira kuendesa mishonga kuura nemazvo, ichitamba isingadzoreki basa mukuchengetedza zvinodhaka, kuderedza gastrointestinal mhedzisiro, nekuvandudza kushanda kwezvinodhaka. Nguva inotevera yaunotora enteric-yakavharwa capsule, pamwe unogona kuva nenzwisiso neruremekedzo rweIchi Invisible Cloak. Kana uchida kudzidza zvakawanda nezve enteric-coated capsules kana mamwe emishonga ekuwedzera, ndapota sununguka kuramba uchititevera.
