Empty Enteric{{0}Coated Capsulesimhando yakakosha yefomu yekuyeresa zvinodhaka. Mabhomba avo akagadzirwa nezvinhu zvakakosha, izvo zvinogona kuramba zvakatsiga pasi pekuita kwegastric acid uye kunyungudika munzvimbo ine alkaline yeura, nekudaro kuwana chaiyo kuburitswa kwezvinodhaka. Iyi dhizaini inounza zvakakosha zvakakosha pakuendesa zvinodhaka uye inoshandiswa zvakanyanya munharaunda yekurapa.
1. Chengetedza Mushonga Kubva Kukuvadzwa neGastric Acid
Kunyanya kukosha kweenteric{0}yakavharidzirwa capsules isina chinhu ndeyekugona kudzivirira mishonga kubva pakukuvadzwa negastric acid. Mishonga yakawanda inogona kurasikirwa nebasa rayo kana kuora pasi pekuita kwegastric acid, nokudaro kuderedza kushanda kwayo. Semuyenzaniso, mamwe mishonga inorwisa mabhakitiriya, mishonga yemaprotein neayo anoda kuburitswa munzvimbo ine alkaline anogona kudzivirira kukanganiswa kweasidhi yemudumbu nekugadzirwa muenteric-yakavharwa macapsules asina chinhu, kuitira kuti mishonga yacho irambe ichishanda kana yasvika mudumbu.
2. Deredza Kushungurudza kuGastric Mucosa
The shell of enteric{0}yakavharidzirwa capsules isina chinhu inogona kuramba yakamira mudumbu, zvoita kuderedza kusvotwa kwemushonga kugastric mucosa. Izvi zvinonyanya kukosha kune mamwe mishonga inogona kukonzera gastrointestinal kusagadzikana. Semuyenzaniso, mishonga yakadai seaspirin, mushure mekugadzirwa muenteric{{3}yakavharidzirwa capsules isina chinhu, inogona kuderedza zvakanyanya kusvotwa mudumbu uye kuderedza kuitika kwekusagadzikana kwegastrointestinal tract.
3. Kuvandudza Bioavailability uye Kushanda Kwezvinodhaka
Enteric-yakavharwa isina chinhu capsules inokwanisa kuburitsa muura yakanangana nekuburitswa kwemishonga uye kunatsiridza bioavailability yemishonga. Nekubuditsa mishonga panzvimbo dzakanangana muura, enteric-yakavharwa capsules isina chinhu inogona kuwedzera nzvimbo yekubatana pakati pemishonga nemudhuri weura, zvichisimudzira kunyudzwa kwemishonga. Iyi chaiyo nzira yekuburitsa zvinodhaka haingokwidzi maitiro ekurapa asiwo inoderedza kurasikirwa kwemishonga mudumbu.
4. Wedzera Nguva Yekuita Kwezvinodhaka
The capsule shell of enteric{0}coated empty capsules ine imwe nhanho yekurarika uye inogona kuita sebuffer mushure mekutora, zvichideredza kukuvadzwa kwemushonga kusvika mudumbu remucosa. Zvichakadaro, iyo capsule shell inogona kudzivirira mushonga kubva pakunyungudika uye kuburitswa nekukasira, nekudaro kurebesa kuita kwemushonga nguva nekuvandudza maitiro ekurapa. Chimiro ichi chinonyanya kukosha kune zvinodhaka zvinoda kuramba zvichienderera mberi kwenguva yakareba.
5. Mamiriro Ekushandisa Akawanda
Enteric-yakavharidzirwa isina capsules inowanzoshandiswa sepakeji yakakosha yemishonga kana zvigadzirwa zvehutano zvinogumbura mudumbu kana kusagadzikana paine acid. Semuyenzaniso, mishonga yemaprotein polypeptide, gadziriro yebhakitiriya mhenyu, nezvimwewo zvinogona kuiswa mumaenteric-akaputirwa macapsules asina chinhu. Pamusoro pezvo, enteric-coated capsules anoshandiswawo zvakanyanya mukurapa zvirwere zvemudumbu nezvisiri{6}}semudumbu zvakaita sekuvhara, colitis uye colorectal cancer. Kuburikidza nemabasa akadai sekudzivirira mushonga, kuburitswa kwezvinodhaka uye kurebesa nguva yekushanda kwemushonga, enteric-makapisi akavharwa anogona kuona kuti mushonga uyu unobudirira mukurapa kwemudumbu, uku uchideredza kusawirirana nekushatirwa.
6. Tekinoroji Kufambira Mberi uye Remangwana Rekuvandudza Madirections
Mumakore achangopfuura, tekinoroji ye-yakavharidzirwa hollow capsules yanga ichienderera mberi, uye michina mitsva nemichina mitsva yagara ichibuda. Semuyenzaniso, kushandiswa kwezvinhu zvitsva zveenteric-zvakavharidzirwa nepolymer kwawedzera kugadzikana uye kunanga kweenteric-yakavharidzirwa hollow capsules. Mune ramangwana, enteric{{5}coated hollow capsule tekinoroji ichasimukira yakanangana nemishonga yekurapa uye nehungwaru. Nekunyatso kudzora mwero wekuburitswa kwemushonga nenzvimbo, zvinosangana nezvinodiwa zvekurapwa kwevarwere chaivo. Pamusoro pezvo, kugadzirwa kwemaenteric{8}}akavharidzirwa macapsules akavharidzirwa, kana asanganiswa net-sensors kuti atarise mamiriro ematumbo uye mamiriro ekubudiswa kwezvinodhaka, zvinounza shanduko yekuchinja kurongwa kwechirwere uye tsvakurudzo yekiriniki.
Summary
Enteric{0}yakavharwa macapsules asina chinhuvanoita basa rakakosha mundima yekurapa nezvavakanakira zvakawanda sekudzivirira zvinodhaka, kuderedza kushatirwa uye kuvandudza mhedzisiro yekurapa. Nekufambira mberi kweruzivo rwemichina, tarisiro yekushandiswa kweenteric-yakavharwa macapsules isina chinhu ichawedzera, ichipa varwere nzira dzekurapa dzakachengetedzeka uye dzakanyanya kushanda. Kana paine chero chinodiwa pamacapsules asina chinhu, unogamuchirwa kubata KornnacCaps.
