Semutakuri wakakosha wekugadzirira kwemishonga, kugadzikana kwegelatin capsules kunokanganisa zvakananga kunaka uye kuchengetedzwa kwezvinodhaka. Pakati pezvinhu zvakasiyana-siyana zvinokanganisa kugadzikana, kupisa denaturation chinhu chakakosha chinoda kunyatsotariswa panguva yekuchengetedza, kutakura, uye kushandiswa kwema capsules aya, sezvo inokonzera zvakananga kutendeseka kwavo kwemaitiro uye kushandiswa kwezvinodhaka.
Gelatin ipuroteni yechisikigo yakakwirira-yemushonga{1}}ine huremu hweprotein ine cheni dzemamorekuru dzinochengetedza katatu-kuumbwa kwehelix kuburikidza nekudyidzana semabhondi ehydrogen. Kana tembiricha yakadzikama ichipfuura kukosha kwayo kwakakosha, aya gelatin mamorekuru cheni anochinja kubva kune yakarairwa helical chimiro kuenda kune isina kurongeka coil chimiro. Iyi nzira inozivikanwa se thermal denaturation. Tembiricha yekupisa yekupisa yegelatin capsules inowanzosvika pakati pe35 dhigirii kusvika 40 dhigirii, ine kukosha chaiko kunokanganiswa nezvinhu zvakaita seye gelatin sosi (semuenzaniso, ganda renguruve, ganda remombe, kana bhonzo rehove), simba rekutumbuka, hunyoro hwemukati, uye marudzi ekuwedzera anoshandiswa. Semuyenzaniso, yakakwira{{11}gelatin yebloom, ine mwero wepamusoro wemolecular chain cross-linking, kazhinji ine tembiricha yakakwirisa, nepo kuwedzera kunyorova kunogona kuderedza mabhondi ehydrogen, zvichiita kuti tembiricha idzikire.
Mhedzisiro yekupisa denaturation pane capsule performance inonyanya kuratidzwa muzvikamu zvitatu. Chekutanga, zvinotungamira mukudzikira kwemagetsi zvinhu; Denatured capsule shells anova akapfava, anorasikirwa nekusimba, uye anowanzo kunamatira, deformation, kana kunyange kuputika. Chechipiri, inoshandura kupinza, sezvo kurongeka patsva kwecheni dzemamorekuru kunogona kuwedzera saizi yepore yemadziro ecapsule, zvichikanganisa kusamira kwemushonga unyoro uye kureruka{2}}kuvharira zvivakwa. Chechitatu, inogona kukonzera kusagadzikana kuparara kwekuita, sezvo denaturation inogona kukanganisa kuzvimba kwegelatin, zvichikonzera kunonoka kana kusashanda kuburitswa kwezvinodhaka. Semuyenzaniso, munzvimbo dzepamusoro-kupisa uye{6}}kunyorova kwepamusoro, macapsules anogona kuratidza Kupfava uye Adhesion phenomenon, zvichikanganisa kurongedza nemashandisirwo awo.
Kuti kuderedze njodzi dzine chekuita nekupisa denaturation, kugadzirwa kwegelatin capsules kunoda optimized formulations. Izvi zvinogona kusanganisira kuisa maplasticizer akaita seglycerin kana sorbitol kuti awedzere kuchinjika kwecheni dzemamolecular kana kushandisa cross-linking agents kunatsiridza kugadzikana kwemafuta. Panguva yekuchengetera, kudzora tembiricha nehunyoro kwakakosha (kunowanzoda tembiricha iri pasi pe25 degrees uye hunyoro huri pasi pe60%), kudzivirira chiedza chezuva uye -nzvimbo dzekupisa. Uyezve, zvinhu zvitsva zve capsule, zvakadai se (hydroxypropyl methylcellulose) HPMC capsules, iyo ine yakanyanya kupisa denaturation tembiricha (inogona kusvika pamusoro pe 70℃), zvishoma nezvishoma inova nzira dzakanakisisa dzekugadzirisa zvinodhaka zvakagadzirirwa nzvimbo dzepamusoro-kupisa.
Mukupedzisa, thermal denaturation chimiro chemukati chegelatin capsulesiyo inofanirwa kutariswa kuburikidza nekugadzirisa zvinhu, kudzora maitiro, uye yakamisikidzwa kuchengetedza. Kunyatsonzwisisa kwechivakwa ichi kwakakosha pakuve nechokwadi chemhando yezvinodhaka, kuwedzera hupenyu hwesherufu, uye inopa hwaro hwekufungidzira hwekutsvagisa nekuvandudzwa kwezvinhu zvitsva zvecapsule. Kana paine chero chinodiwa pamacapsules asina chinhu, unogamuchirwa kubata KornnacCaps.
