Semutakuri akakosha mukugadzirwa kwemazuva ano kwemishonga, kushanduka kwemakapule asina chinhu anoratidza kufambira mberi kwemishonga kubva pachinyakare kuenda kune yazvino maitiro. Mushonga uyu unoratidzika kunge wakareruka haangogadzirise nyaya dzakaita sekuvava uye kushatirwa kwemishonga panguva yekutonga asi zvakare yakasimudzira chiyero uye chiyero cheindasitiri yemishonga, ichiva chinhu chakakosha mumafomu emushonga.
Iyo prototype yemacapsules inogona kurondwa kumashure kuEgypt neGreece yekare, uko vanhu vaishandisa ura hwemhuka kana wakisi kuputira mishonga kuvhara kunhuhwirira kusingafadzi kana kufambisa kumedza. Nekudaro, iyo yechokwadi isina chinhu hard capsule yakazvarwa pakati pe19th century France. Muna 1834, mufesi weParisian Achille Colas akagadzira nzira yekugadzira mawoko magelatin capsules nekunyudza molds kuti aumbe capsule shells, kuwana yakamisikidzwa zvinodhaka encapsulation kekutanga. Kugadzirwa uku kwakakurumidza kupararira muEurope ndokusvika kuUnited States pakupera kwezana ramakore rechi 19, zvichipa kusimudzira kugadzirwa kwecapsule.
Mukutanga kwezana ramakore re20th, nekusimuka kweindasitiri yemishonga, tekinoroji yekugadzira yemacapsules asina chinhu akaomarara yakawana budiriro huru. Muna 1912, mufesi weAmerica Robert Paul Scherer akagadzira otomatiki capsule yekugadzira muchina, ichigonesa kuenderera kugadzirwa uye zvakanyanya kuvandudza zvese kushanda uye kuenderana kwechigadzirwa. Munguva iyi, gelatin yakave yakashandiswa zvakanyanya seyekutanga capsule material, uye capsule sizes zvishoma nezvishoma zvakagadziriswa, zvichiita ikozvino{4}} common size system kubva 00 kusvika 5.
Mushure meHondo Yenyika II, nekuwedzera kwemusika wepasi rose wemishonga, iyo isina chinhu yakaoma capsule indasitiri yakapinda munguva yekukura nekukurumidza. Mumakore ekuma1960, kuuya kwemaenteric-akaputirwa capsules kwakagadzirisa dambudziko rekuti zvinodhaka zviparadzwe zviri nyore mudumbu. Mumakore ekuma1970, makapusi emuriwo akabuda kuti asangane nezvido zvevarimi uye vanhu vane zvitendero chaizvo. Tichipinda muzana remakore rechi21, kushandiswa kwezvinhu zvitsva zvepolymer kwaita kuti kugadzirwa kwemakapisiti anoshanda, akadai -akaburitsa macapsules uye akanangwa-macapsules anoburitsa, zvinosimbisa kurapa kwakanyanya.
Panguva imwecheteyo, maitiro ekugadzira akashanduka kubva kune yechinyakare diping nzira kuenda kune yakanyatso kudonhedza nzira, ichiwedzera kugona kwekugadzira kakapetwa kakawanda. Mitsetse yemazuva ano yekugadzira macapsules ava kuratidza otomatiki kutonga, nemhando yechigadzirwa ichisangana nemishonga-yegiredhi. Kugadzirwa kwekapsule kwepagore kwepasi rose kwapfuura chidimbu chetiririyoni, neChina, United States, neJapan vari ivo vanotungamira vagadziri.
Nhasi,isina chinhu yakaoma capsulesdzakashanduka kubva muchishandiso chiri nyore chekuendesa zvinodhaka kuenda kune-chigadzirwa chepamusoro chekuendesa zvinodhaka. Haangotakuri zvinosanganisa mishonga yemishonga chete asi zvakare anoratidza kushingirira kwevanhu kutsvaga kwechokwadi mukutonga kwezvinodhaka. Nekubudirira mune 3D tekinoroji yekudhinda, nanomaterials, uye akangwara anopindura zvinhu, asina chinhu akaoma capsules akaiswa kuti apenye zvakatonyanya kupenya muminda yemunhu wega, gene therapy, uye yakanangwa kuendesa zvinodhaka, vachienderera mberi nekunyora chitsauko chakajeka mukufambira mberi kwesainzi yemishonga uye tekinoroji. Kana paine chero chinodiwa pamacapsules asina chinhu, unogamuchirwa kubata KornnacCaps.
