Seimwe yezvinowanzo shandiswa zvinoyamura mukugadzira mishonga, kuzvimba pfuma yegelatin capsules chinhu chakakosha chemuviri chinokanganisa chiyero chekuburitswa kwemishonga uye bioavailability. Kuzvimba kunoreva chiitiko apo goko recapsule rinotora mvura uye rinowedzera vhoriyamu kana rasangana nesvikiro rine mvura. Iyi nzira inosarudza zvakananga nguva yekapsule yekuparara uye maitiro ekuparara kwezvinodhaka.
Kuzvimba kwegelatin capsules kunogona kukamurwa kuita nhanho nhatu: nhanho yekutanga yekunyorova, nhanho yekuzvimba nekukurumidza, uye nhanho yekuzvimba. Kana iyo capsule ikasangana neine aqueous medium, mapoka ehydrophilic ari pagelatin molecular chain (senge -COOH ne- NH2) anokurumidza kuumba hydrogen bonds nemamorekuru emvura, achinyorovesa capsule pamusoro. Zvadaro, mamorekuru emvura anopinda muzvikamu zvitatu zvegelatin-zviyero zvenetiweki kuburikidza neosmosis, zvichikonzera kuwedzera kwechinhambwe chiri pakati pecheni dzemamorekuru uye kuwedzera kukuru kwevhoriyamu yecapsule. Ongororo dzakaratidza kuti pa37℃, kuzvimba kwegelatin capsules kunogona kusvika 200%-300%, kunopedzisira kwaita gel-like structure.
Zvinhu zvinokanganisa kuzvimba kwegelatin empty capsules kunyanya zvinosanganisira gelatin source,℃of cross-linking, ambient temperature, uye medium pH. Zvisikwa zvakasiyana zvemhuka (zvakadai seganda renguruve, bovine dehwe, kana bhonzo rehove) zvinokonzeresa mutsauko mukuumbwa kweamino acid uye kugoverwa kwema molecular huremu hwegelatin, iyo inokanganisa zvakananga kugona kwayo kwemvura. Mederate cross{{3}linking inogona kuwedzera simba re capsule, asi kuwandisa kuchinjika-kubatanidza kunogona kutadzisa mvura kupinda uye kuderedza kuzvimba. Kuwedzera kwekushisa kunomhanyisa kufamba kwema molecular uye kunokurudzira kuzvimba, nepo acidic kana alkaline nharaunda inogona kushandura mamiriro ekuchaja egelatin molecular cheni, zvichikanganisa hydration yavo.
Mumashandisirwo anoshanda, kuzvimba kwegelatin capsules kune mbiri mbiri pakuburitswa kwezvinodhaka. Kune rumwe rutivi, kuzvimba kwakakodzera kunovimbisa kuti iyo capsule inoparara nekukurumidza mudumbu remukati, ichikurudzira kupera kwezvinodhaka. Nekune rumwe rutivi, kukurumidza kukurumidza kuzvimba kunogona kukonzera kuraswa kwezvinodhaka, nepo kusazvimba kwakakwana kunogona kukonzera kuburitswa kwezvinodhaka zvisina kukwana. Nokudaro, nekugadzirisa rudzi rwegelatin, kuwedzera plasticizers (yakadai se glycerin), kana kubatanidza surfactants, kuzvimba maitiro e capsules kunogona kunyatsogadziriswa kuti asangane nezvinodiwa zvekusunungurwa kwemishonga yakasiyana.
Nekufambiswa kwehunyanzvi hwekugadzira tekinoroji, tsvakiridzo yekuzvimba kwegelatin capsules yakafambira mberi kubva kune macroscopic phenomena kuenda kumamorekuru maitiro. Kushandiswa kwemaitiro echizvino-zvino ekuongorora, akadai seDifferential Scanning Calorimetry (DSC) uye Dynamic Mechanical Analysis (DMA), yakapa maturusi ane simba ekuburitsa pachena shanduko yekuchinja kwemamorekuru panguva yekuzvimba. Mune ramangwana, kuburikidza nemajini einjiniya yegelatin yakagadziridzwa kana kusikwa kwekombiji nemapolymeri echisikigo, zvinotarisirwa kuti novel capsule masisitimu ane hungwaru mhinduro dzekuzvimba achagadziridzwa, achienderera mberi kufambisira mberi munda wehunyanzvi hwekuunza zvinodhaka. Kana paine chero zvinodikanwa pamacapsules asina chinhu, gamuchirai kuti tibataneKornnacCaps.
